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You may get pregnant if you do not use Mircette regularly.

Some of these metabolites, such as 15α-OHE 2, are excreted in relatively large amounts in pregnant women, possibly serving as an indicator of good health.

Meta analysis of 51 studies (epidemiological data) supports a modest risk increase associated with long-term hormone replacement therapy (HRT).

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Estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease".

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Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells".

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Do not apply any brand of estradiol patches to the breasts or to skin that is oily, damaged, cut, or irritated.

Some minor drug interactions may not be clinically relevant in all patients.

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Cohen L, Coxwell WL, Melchione T, Koltun W, Gibson E, Gupta N, Roberts M "Low-dose 17-beta estradiol matrix transdermal system in the treatment of moderate-to-severe hot flushes in postmenopausal women.

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